INVESTIGATIONS ON CHANGES OF SERUM MAGNESIUM CONCENTRATION AFTER GLUCAGON APPLICATION IN HEALTHY HUMANS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 37  (3) , 441-445
Abstract
The effect of i.v. application of 1 mg glucagon on serum Mg concentration, K, immunoreactive insulin (IRI) and blood glucose in healthy subjects was studied. A significant decrease of the serum Mg concentration was observed beginning 5 min after glucagon injection. There was a tendency of a slight but not statistically significant decrease of K level at 60 min. The beginning of the decrease of Mg level was associated with the maximum of IRI-peak. In contrast to the discussed hypothesis that hyperglycemia and hyperinsulinemia cause a shift for Mg and K from the extracellular into the intracellular space, hyperglycemia is not a necessary condition for the decreasing effect of glucagon on serum Mg level.

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