Chemistry of tremorogenic metabolites. I. Fumitremorgin a from Aspergillus fumigatus.

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Abstract
Two new indolic metabolites, fumitremorgin A and B, were isolated from the fungus A. fumigatus. These 2 metabolites caused severe tremor and convulsion in experimental animals [mice, rats and rabbits]. The structure of fumitremorgin A, including the stereochemistry, was determined on the basis of the spectral data for the compound and some derivatives obtained from it. The stereochemical factors affecting the appearance of tremorogenic activity in fumitremorgin A and related compounds are discussed. A. fumigatus is a frequent contaminant of rice and miso (soybean paste).

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