Dietary Restriction Alone and in Combination With Oral Ethoxyquin/2-Muercaptoethylamine in Mice

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Abstract
To investigate effects of dietary caloric restriction (DR) combined with antioxidant feeding, long-lived hybrid mice were divided into four dietary groups at weaning, and followed until natural death. Groups “C” and “R” received control (97 kcal/wk) and restricted (56 kcal/wk) diets respectively. Groups “C +αox” and “R + αox” received C or R diets supplemented with an antioxidant mixture (2-mercaptoethylamine plus ethoxyquin). R mice (mean life span 41 months) significantly outlived the other three groups (mean life span 30–34 months). Hepatic degeneration and increased hepatoma in the R + αox group suggested unusual hepatotoxicity of this regimen. Antioxidants had little effect on splenic cell mitogen response in similarly fed mice sacrificed at 12–15 months. Gompertz analysis suggests that the beneficial effect of DR may be due to reductions in initial vulnerability or rate-of-aging parameters, or both, and that the relative influence of each factor may vary with animal strain and DR protocol used.

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