Reactions with Aziridines; 341. γ-Amidoketones by Amidoethylation of Ketones
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (05) , 392-395
- https://doi.org/10.1055/s-1986-31648
Abstract
Sodium enolates of ketones react with 1-acyl-, 1-aminocarbonyl-, and 1-alkoxycarbonylaziridines to give γ-amidoketones ([N-(4-oxoalkyl)-carboxamides, -ureas, and -carbamic esters]. Twofold amidoethylation in α,α- or α,α′-position can usually be suppressed by using excess enolate, exept for the amidoethylation of 1-indanone.Keywords
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