Pulmonary Absorption and Retention of Kanamycin After Repeated Inhalation Administration of Kanamycin Aerosol

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Abstract
The absorption and retention of kanamycin by the pulmonary system was evaluated after aerosol administration to rats. Tissue level concentrations of the drug were assayed by the agar-plate bioassay method. Mean concentrations of 6.58 μg/g and 3.52 μg/g were found in the lung and kidney homogenates, respectively, 26 hr after the final exposure period. No detectable level was found in the plasma.

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