Release of Endogenous Digitalis-like Factor with Sodium Loading

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Abstract
To the Editor: There is considerable evidence to support the idea that the putative natriuretic hormone is involved in extracellular-fluid volume homeostasis and the pathophysiology of hypertensive diseases.1 2 3 4 5 This substance has been described as an endogenous digitalis-like factor with an ability to inhibit sodium–potassium–ATPase. The conservation of a specific digitalis-binding site with a high affinity and specificity for sodium–potassium–ATPase certainly argues in favor of the presence of an endogenous ligand. Researchers have sought to identify the relevant digitalis-like factor for more than 20 years, but its isolation has proved difficult.We have recently purified to homogeneity a polar digitalis-like factor . . .