Effects of nucleotides on expression of the folate sensitive fragile sites

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Abstract
Further studies on the effect of nucleotides upon expression of the folate sensitive fragile sites have confirmed that high concentrations of thymidine (300 mg/l) but not BrdU (600 mg/l) induce these fragile sites. Induction by thymidine can be supressed by addition of cytidine in a dose response manner. Studies on other nucleotides suggest that guanosine, but not adenosine or cytidine, can induce the fragile sites. The previously hypothesised model for the DNA at a fragile site as a naturally occurring polypurine/polypyrimidine sequence which becomes amplified is further developed.