The Role of Dietary Protein Restriction in Progressive Azotemia
- 31 March 1994
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 330 (13) , 929-930
- https://doi.org/10.1056/nejm199403313301310
Abstract
In rats, renal diseases progress to the end stage, but the rate of progression can be slowed dramatically by dietary protein restriction1. In humans, most renal diseases also progress to death due to uremia, unless transplantation or dialysis is provided2. Despite several studies to the contrary, the results of the Modification of Diet in Renal Diseases (MDRD) study, reported in this issue of the Journal by Klahr et al., suggest that the progression of renal diseases in humans is only minimally slowed by dietary protein restriction3. What accounts for these differences?In the studies in rats the . . .Keywords
This publication has 4 references indexed in Scilit:
- The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal DiseaseNew England Journal of Medicine, 1994
- Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat.Journal of Clinical Investigation, 1992
- The Progression of Renal DiseaseNew England Journal of Medicine, 1988
- Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.Journal of Clinical Investigation, 1985