Gastric "Freezing" in Peptic Ulcer

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Abstract
One hundred patients were followed for 9 months or longer after gastric "freezing" for peptic ulcer. Sixty six showed improvement at 3 weeks. This number decreased to 52 in 3 months, 27 in 6 months and 18 in 9 months. Serial X-rays showed improvement during the first 3 weeks and 3 months in some patients. Fifty four patients had duodenal ulcer craters prior to the freeze treatment. Twenty five of these 54 showed disappearance of the ulcer crater. However 12 of these had crater recurrence (2 in 3 months, 4 in 6 months, and 6 in 9 months). Gastric secretory studies demonstrated a temporary reduction in volume and acid output. Almost all decreases returned to prefreeze levels within 3 weeks. The concept of partial vagotomy as the physiological mechanism involved is supported by the secretory findings. Destruction of gastric mucosa is not necessary to produce this effect. Limited therapeutic success occurred in this series of single freeze treatments because of the brief duration of clinical improvement.

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