Mitochondrial mutations may drive Y chromosome evolution
- 28 February 2002
- Vol. 24 (3) , 275-279
- https://doi.org/10.1002/bies.10062
Abstract
The human Y chromosome contains very low levels of nucleotide variation. It has been variously hypothesized that this invariance reflects historic reductions in the human male population, a very recent common ancestry, a slow rate of molecular evolution, an inability to evolve adaptively, or frequent selective sweeps acting on genes borne on the Y chromosome. We propose an alternative theory in which human Y chromosome evolution is driven by mutations in the maternally inherited mitochondrial genome, which impair male fertility and ultimately lead to a reduction in the effective population size (Ne) and consequently the variability of the Y chromosome. BioEssays 24:275–279, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10062Keywords
This publication has 32 references indexed in Scilit:
- Y chromosome polymorphism is a strong determinant of male fitness in Drosophila melanogasterProceedings of the National Academy of Sciences, 2001
- Mitochondrial genome variation and the origin of modern humansNature, 2000
- Y chromosome sequence variation and the history of human populationsNature Genetics, 2000
- Population genetic implications from sequence variation in four Y chromosome genesProceedings of the National Academy of Sciences, 2000
- Recent common ancestry of human Y chromosomes: Evidence from DNA sequence dataProceedings of the National Academy of Sciences, 2000
- Human evolution: Sex-specific contributions to genome variationCurrent Biology, 1999
- A selective difference between human Y-chromosomal DNA haplotypesCurrent Biology, 1998
- Sex biases in the mutation rateTrends in Genetics, 1998
- Sequence variation of the human Y chromosomeNature, 1995
- Absence of Polymorphism at the ZFY Locus on the Human Y ChromosomeScience, 1995