Decreased adrenomedullin production in the coronary circulation of patients with coronary artery disease
Open Access
- 1 July 2000
- Vol. 84 (1) , 88
- https://doi.org/10.1136/heart.84.1.88
Abstract
Adrenomedullin is a novel peptide first isolated from human pheochromocytoma1 and later proved to be secreted from the adrenal medulla, heart, vascular smooth muscle cells, and endothelial cells.2 Adrenomedullin has not only vasoactive but also antimitogenic effects on the vascular tissue.3However, endothelin-1 has been widely known to be a potent atherogenic factor.4 We investigated adrenomedullin and endothelin-1 production in the coronary circulation of patients with coronary artery disease. We studied 18 patients with coronary artery disease (12 men and six women, mean age 61.2 (10.0) years, range 36–83 years) and seven control subjects without coronary artery lesions (six men and one women, mean age 60.0 (10.5) years, range …Keywords
This publication has 7 references indexed in Scilit:
- Plasma levels of adrenomedullin in patients with mitral stenosisAmerican Heart Journal, 1998
- Adrenomedullin Increases Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells Stimulated With Interleukin-1Hypertension, 1996
- Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cellsJournal Of Hypertension, 1996
- Inhibition of Endothelin Production by Adrenomedullin in Vascular Smooth Muscle CellsHypertension, 1995
- AdrenomedullinDrugs, 1995
- Endothelin production in pulmonary circulation of patients with mitral stenosis.Circulation, 1994
- Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loopJournal of Biological Chemistry, 1994