The effect of administration of an acetate on the detoxication and therapeutic activity of sulphanilamide. II

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Abstract
Both sulphanilamide and sulphapyridine are toxic due to withdrawal of acetate precursors and lowering of the CO2 capacity of the blood. Acetate given at the same time rectifies this defect. Acetylsulphanilamide evidently exerts a specific toxic effect although it must also have some effect on the respiratory centre on account of the fall of CO2.