CORRELATION BETWEEN SINGLE FIBRE EMG JITTER AND ENDPLATE POTENTIALS STUDIED IN MILD EXPERIMENTAL BOTULINUM POISONING

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Abstract
To study the correlation between single fiber EMG [electromyograph] jitter and endplate potential amplitude, neuromuscular transmission in rats paralyzed with botulinum toxin type A was examined with single fiber EMG (SFEMG) in vivo and with intracellular microelectrode techniques in vitro. In muscles that were not completely paralyzed, SFEMG showed an increased neuromuscular jitter on nerve stimulation, and in these muscles endplate potentials were of reduced amplitude. When the nerve stimulation frequency increased the jitter decreased. Injection [i.v.] of drugs that increase the acetylcholine release and endplate potential amplitude markedly reduced the jitter and the frequency dependence disappeared.