Pharmacokinetics of dibekacin in rabbits and dogs.

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Abstract
The behaviors of the antibiotic dibekacin after 3 administration methods to rabbits and dogs were pharmacokinetically analyzed. In both rabbits and dogs, the pharmacokinetic constants for the i.v. constant infusion and i.m. injection were similar to each other, and the serum levels after the i.v. constant infusion for 1 h were similar to those after the i.m. injection except the peak time. In both rabbits and dogs, Vd [volume distribution] increased with the dose and a linear correlation was noted between log Vd and log (dose). The tissue concentrations of dibekacin decreased with the decrease in the serum concentration. A correlation equation, log T1/2 = 0.194.cntdot.log B + 1.128, was obtained, where T1/2 and B represent the biological half-life of dibekacin and the body weight of animals, respectively. The pharmacokinetic behaviors of dibekacin in human beings can be predicted from the results of the animal experiments.

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