Factors Influencing the Efficacy of Phenolized Rabies Vaccines: II. Virus Content of Vaccine

Publisher Website
Google Scholar
Abstract
The degree of immunity produced in mice depends on the virus content of phenolized rabies vaccines. Virus content of paralyzed rabbit brains is higher if the animals are allowed to re-main paralyzed 1-2 days before being killed and if a 1:1000 dilution is used as inoculum instead of a heavy emulsion. Cords of rabbits usually have a lower virus titer than brains. The method of killing rabbits and the rapidity of animal passage of the virus apparently do not influence the virus content of the brains. Storage of rabies brains in glycerin before emulsification may reduce the amt. of demonstrable virus.

This publication has 3 references indexed in Scilit: