Abstract
The inability of Drs. Stein, Ablin, Kushner and Zoger, in their Letter to the Editor1, to "see what good can come of exaggerating the effectiveness of current therapy" for childhood leukemia is not surprising. They imply that others have such distorted vision that they see castles where only hovels stand. The implication of Dr. Stein and his colleagues, were it true, would be damning. I believe that faulty logic, poor data, sketchy analysis, and embellished accounts in the popular press over which the interviewed exercises no editorial control led these correspondents to improper conclusions. In the design of clinical investigations to explore potentially improved therapeutic approaches to acute lymphocytic leukemia, the Acute Leukemia Group B has structured from two to five regimens into concurrent comparisons on a multi-institutional level.

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