The effects of hyperthermia on vascular permeability in experimental liver metastasis

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Abstract
The effects of hyperthermia on vascular permeability in Walker carcino‐sarcomas and host liver tissue were studied in Sprague‐Dawley rats. A quantitative Evans blue technique was used to measure permeability. With tumors heated to 40° C, a nontherapeutic level, no changes in tumor vascular permeability as compared to control levels were noted. However, with tumors heated to 43° C, within the therapeutic range of hyperthermia, significant rises in tumor vascular permeability occurred. Permeability was increased at both time periods studied, 30 minutes and 6 hours after hyperthermia and injection of Evans blue. These changes are similar to those seen after physical damage from freeze‐thaw. It is likely that alterations in tumor microcirculation play a role in the therapeutic effect of intense hyperthermia.