LIVER AND IMMUNE RESPONSES

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Abstract
Rat liver cells prepared by collagenase treatment and separated by density gradient centrifugation with Ficoll-Hypaque solution (specific gravity 1.120), containing only hepatocytes (80%) and Kupffer cells (20%), strongly stimulated Ag-B-incompatible lymphocytes without 2-mercaptoethanol in culture. The same liver cells could be also stimulate Ag-B-compatible lymphocytes in the presence of 2-mercaptoethanol. A positive response was only seen when the liver cell numbers were 1 .apprx. 2% of the responding lymphocytes. Viable liver cells inhibited the reaction in a 2-way culture.

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