Immunogenicity of 1967 Polyvalent and 1968 Hong Kong Influenza Vaccines

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Abstract
Influenza A2 vaccine containing 300 chick-cell agglutination (CCA) units per dose of the Hong Kong variant provided a high degree of protection during an outbreak of respiratory illnesses in military personnel in December 1968 and January 1969. This inactivated chicken embryo-propagated virus vaccine stimulated hemagglutination-inhibition antibody responses that were equivalent to natural infection. Polyvalent vaccine, 1967 formula, was not without some contribution in preventing disease in those who did not receive Hong Kong influenza vaccine. Influenza A2 comprised 56% of all respiratory illnesses during the outbreak. Virus was isolated in rhesus monkey kidney cultures from pharyngeal washings of a third of the individuals with serologic evidence of infection by influenza A2.

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