An extensive network of coupling among gene expression machines
Top Cited Papers
- 4 April 2002
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 416 (6880) , 499-506
- https://doi.org/10.1038/416499a
Abstract
Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form ‘gene expression factories’ that maximize the efficiency and specificity of each step in gene expression.Keywords
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