Unusual cytogenetics in a case of acute lymphoblastic leukemia
- 1 January 1979
- journal article
- case report
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 7 (3) , 257-262
- https://doi.org/10.1002/mpo.2950070311
Abstract
The cytogenetics in the study of a patient with acute lymphoblastic leukemia are presented. Initially, a large proportion of both unstimulated and phytohemagglutinin (PHA)-stimulated blood mitoses showed an abnormal karyotype with a 7;12 translocation and a trisomy 19. At the time of relapse, a PHA-stimulated culture showed the clonal abnormality as well as dicentric chromosomes in normal cells, the latter possibly resulting from treatment.Keywords
This publication has 7 references indexed in Scilit:
- Cytogenetic studies of chronic myelocytic leukemia in children and adolescentsCancer, 1979
- Acute nonlymphoblastic leukemia in childhood. High incidence of clonal abnormalities and nonrandom changesCancer, 1979
- Multiple keukemic clones in acute leukemia of childhoodHuman Genetics, 1978
- Non-leukemic dividing cells in the blood of leukemic patientsAmerican Journal of Hematology, 1978
- Karyotyping of bone-marrow cells in hematologic diseasesHuman Genetics, 1977
- PHILADELPHIA CHROMOSOME IN P.H.A.-STIMULATED LYMPHOCYTES IN ACUTE LEUKÆMIAThe Lancet, 1975
- Chromosomes and causation of human cancer and leukemia.IX. Prognostic and therapeutic value of chromosomal findings in acute myeloblastic leukemiaCancer, 1974