Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis
Open Access
- 1 October 1981
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 44 (4) , 567-571
- https://doi.org/10.1038/bjc.1981.227
Abstract
Resistance to the cytocidal action of Adriamycin (ADR) was induced in rat hepatocytes by incorporation of the carcinogen 2-acetylaminofluorene (AAF) into the rat diet. Using a quantitative assay in primary monolayer culture, it was demonstrated that resistance to ADR is an early phenotypic change that is induced during chemical carcinogenesis in the rat, and appears to be stable.Keywords
This publication has 13 references indexed in Scilit:
- Therapy of local toxicities caused by extravasation of cancer chemotherapeutic drugsCancer Treatment Reviews, 1980
- The role of antitumor antibiotics in current oncologic practiceCancer Chemotherapy and Pharmacology, 1978
- In vitro measurement of carcinogen‐resistant liver cells during hepatocarcinogenesisInternational Journal of Cancer, 1978
- RAPID EMERGENCE OF CARCINOGEN-INDUCED HYPERPLASTIC LESIONS IN A NEW MODEL FOR SEQUENTIAL-ANALYSIS OF LIVER CARCINOGENESIS1977
- TUMORIGENICITY INVIVO AND INDUCTION OF MALIGNANT TRANSFORMATION AND MUTAGENESIS IN CELL-CULTURES BY ADRIAMYCIN AND DAUNOMYCIN1976
- The Interaction of Chemical Carcinogens and Cells in vitro1Published by S. Karger AG ,1969
- A Clonal Selection Theory of Chemical Carcinogenesis2JNCI Journal of the National Cancer Institute, 1964
- Sensitivity of Normal and Neoplastic Cells to the Damaging Action of Carcinogenic Substances: A ReviewJNCI Journal of the National Cancer Institute, 1963
- SIMILARITIES IN THE SEQUENCE OF EARLY HISTOLOGICAL CHANGES INDUCED IN THE LIVER OF THE RAT BY ETHIONINE, 2-ACETYLAMINO-FLUORENE, AND 3'-METHYL-4-DIMETHYLAMINOAZOBENZENE1956
- [Histopathological study of the lesions produced by 2-acetylaminofluorene in different organs of the rat].1952