Involvement of fusion activity of ultraviolet light-inactivated sendai virus in formation of target antigens recognized by cytotoxic T cells
Open Access
- 1 July 1978
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 148 (1) , 276-287
- https://doi.org/10.1084/jem.148.1.276
Abstract
Mice inoculated with ultraviolet light-inactivated Sendai virus mount a cell- mediated immune response to the virus. Cytotoxic T cells specific for Sendai virus can be obtained by in vitro secondary stimulation of primed spleen cells with syngeneic stimulator cells coated with UV-inactivated Sendai virus. Neither in vivo nor in vitro stimulation alone is sufficient to generate specific cytotoxic T cells. Sharing of the H-2 haplotype between cytotoxic T cells and target cells is required for the Sendai virus-specific lysis to occur.This publication has 28 references indexed in Scilit:
- T-cell cytotoxicity in the absence of viral protein synthesis in target cellsNature, 1977
- Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses.The Journal of Experimental Medicine, 1977
- Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex.The Journal of Experimental Medicine, 1977
- T-lymphocyte response to Friend virus-induced tumour cell lines in mice of strains congenic at H–2Nature, 1976
- SPECIFIC IMMUNE LYSIS OF PARAMYXOVIRUS-INFECTED CELLS BY COMPATIBLE-H-2 THYMUS-DERIVED LYMPHOCYTES1976
- Functional interactions of viral and histocompatibility antigens at tumor cell surfaces.Proceedings of the National Academy of Sciences, 1975
- Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifierNature, 1975
- In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.The Journal of Experimental Medicine, 1975
- Target cell‐dependent T cell‐mediated lysis of vaccinia virus‐infected cellsEuropean Journal of Immunology, 1975
- Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoidsBiochemical Journal, 1961