Rat Liver Glutamate Formiminotransferase Activity in B12 Deprivation and Germ Free Conditions

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Abstract
The activity of the liver enzyme, glutamate formiminotransferase, has been reexamined in B12 supplementation and in germfree conditions. The data indicated that under conventional conditions, B12 supplementation resulted in increased serum S. faecalis folate, decreased serum L. casei total folate levels, and increased liver glutamate formiminotransferase activity. Using essentially the same diet supplemented with minimal amount of B12 and using germfree animals, results were obtained indicating that the controls of folate metabolism and liver glutamate formiminotransferase activity are not under direct influence of B12 supplementation.