Dose-Proportional Absorption of Etretinate After Doses of 25, 50, 75, and 100 mg
- 1 January 1987
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 04 (5) , 420-424
- https://doi.org/10.1023/a:1016494531044
Abstract
Twelve healthy male subjects received single oral doses of etretinate, ranging from 25 to 100 mg (1 to 4 × 25-mg capsules) in an open-label, four-way randomized crossover design. Plasma concentrations of etretinate and two active metabolites were determined by a specific high-performance liquid chromatographic (HPLC) method. Analysis of variance and orthogonal contrasts were used to assess dose proportionality. Mean (± %CV) maximum concentrations after 25- to 100-mg doses were 133 (50), 195 (33), 261 (53), and 446 (65) ng/ml, whereas AUC0−12 values were 581 (46), 1090 (39), 1500 (52), and 2440 (63) ng · hr/ml, respectively. The test for proportionality indicated that Cmax and AUC0−12 increased proportionally with an increase in dose (P > 0.05).This publication has 6 references indexed in Scilit:
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