EFFECTS OF RENAL-FAILURE ON LEUKOTAXIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 10  (4) , 267-278
Abstract
Effects of renal failure and experimental azotemia on in vitro leukocyte migration were studied. Migration of normal leukocytes in sera from patients with untreated renal failure was regularly decreased, while sera from patients on chronic dialysis exerted no inhibitory effect. Serial sera obtained from 2 patients starting chronic dialysis exhibited a gradual decrease and ultimate disappearance of the serum inhibitory effect. Experimental azotemia serum supported increased migration of normal leukocytes. Leukocytes from renal failure patients migrated normally when incubated in autologous uremic serum or in normal homologous serum. Serum from untreated renal failure patients apparently inhibits in vitro migration of normal leukocytes. This inhibitory capacity is apparently correctable by hemodialysis.

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