C3 Variants in Japanese

Abstract
By high-voltage agarose gel electrophoresis, 7 phenotypes of [complement]C3 were found in Japanese. The allele frequencies for C3*S, C3*S025, C3*S02, C3*F, C3*F06, C3*F065 and C3*F08 were 0.9943, 0.0003, 0.0003, 0.0006, 0.0003, 0.0021 and 0.0021, respectively. CH50, C3/C3c protein concentrations, and C3 hemolytic activities in fresh sera with variant C3 phenotypes were within the normal ranges.