An Engineered Disulfide Bond between Residues 69 and 238 in Extended-Spectrum β-Lactamase Toho-1 Reduces Its Activity toward Third-Generation Cephalosporins
- 24 November 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 43 (50) , 15737-15745
- https://doi.org/10.1021/bi048488u
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Acyl-intermediate Structures of the Extended-spectrum Class A β-Lactamase, Toho-1, in Complex with Cefotaxime, Cephalothin, and BenzylpenicillinJournal of Biological Chemistry, 2002
- Structure of an extended-spectrum class A β-lactamase from Proteus vulgaris K1Journal of Molecular Biology, 2002
- The High Resolution Crystal Structure for Class A β-Lactamase PER-1 Reveals the Bases for Its Increase in Breadth of ActivityJournal of Biological Chemistry, 2000
- Role of Ser-237 in the substrate specificity of the carbapenem-hydrolyzing class A β-lactamase Sme-1Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1999
- Crystal structure of the E166A mutant of extended-spectrum β-lactamase toho-1 at 1.8 Å resolutionJournal of Molecular Biology, 1999
- X-ray Analysis of the NMC-A β-Lactamase at 1.64-Å Resolution, a Class A Carbapenemase with Broad Substrate SpecificityJournal of Biological Chemistry, 1998
- Mechanism of turnover of imipenem by the TEM .beta.-lactamase revisitedJournal of the American Chemical Society, 1995
- Contribution of mutant analysis to the understanding of enzyme catalysis: The case of class A β-lactamasesBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1995
- Refined crystal structure of β-lactamase from Staphylococcus aureus PC1 at 2.0 Å resolutionJournal of Molecular Biology, 1991
- A fast algorithm for rendering space-filling molecule picturesJournal of Molecular Graphics, 1988