Intestinal Blood Flow in Curarization

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Abstract
Intraarterial injn. of d-tubocurarine to innervated and denervated perfused segments of dog intestine increased blood flow through the segments and decreased intestinal tonus and rhythmical contractions. The increased flow is ascribed to a dilatatory action on intestinal vasculature. Atropinization, which inhibited intestinal tonus and contractility, caused only minor increase in blood flow and did not interfere with the vasodilatatory action of d-tubocurarine. The vascular response of intestine to d-tubocurarine, unlike that of striated muscle, exhibits no appreciable tachyphylaxis. The results demonstrate that the splanchnic vasculature contributes significantly to generalized circulatory reaction to d-tubocurarine.

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