FURTHER STUDIES IN MUSCLE FATIGUE AND PERMEABILITY

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Abstract
Experiments on nerve-muscle preparations of Rana esculenta with indirect stimulation (condenser discharges) show that in a Ringer solution containing an excess of CaCl2 fatigue is delayed. None of the other alkali earths can replace Ca. Sr, Mg, and Ba, added to the ordinary Ca content of Ringer''s solution, also delay fatigue, but to a lesser degree than Ca. BaCl2 in very low concentrations causes a contrac-ture of stimulated muscles. This, as well as the other facts, seems to indicate that the permeability of the muscle is increased by indirect stimulation, since the delay of fatigue is obtained in both directly and indirectly stimulated muscles under the same conditions. The nature of the increase in permeability seems to be the same in both cases if stimulation with super-maximal currents is avoided. The experiments furnish a new illustration of the increase in permeability of muscles under physiological (nerve) stimulation.

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