NORADRENALINE RELEASE IN HUMAN CORPUS CAVERNOSUM AND ITS MODULATIONVIAPRESYNAPTIC α2‐ADRENOCEPTORS

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Abstract
Summary—Strips of human corpus cavernosum were incubated with3H‐noradrenaline and subsequently superfused with physiological salt solution containing desipramine and corticosterone. The electrically (0.66 Hz) evoked tritium overflow was abolished by tetrodotoxin or omission of Ca2+from the superfusion fluid. The α2‐adrenoceptor agonist B‐HT 920 (6‐allyl‐2‐amino‐5, 6, 7, 8–4H‐thiazolo‐5,4‐d‐azepine), inhibited the evoked overflow, whereas the α1‐adrenoceptor agonist, methoxamine, was ineffective. The α2‐adrenoceptor antagonist, rauwolscine, facilitated the evoked tritium overflow. It is concluded that the stimulation‐evoked release of noradrenaline from the sympathetic nerve fibres of the human corpus cavernosum is modulated via presynaptic α2‐adrenoceptors.