Syntheses of α-linked derivatives of N-acetyl glucosamine and Gal-β(1-3)GalNAc (T antigen) directly with the natural N-acetyl protecting group
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 1918-1919
- https://doi.org/10.1039/c39890001918
Abstract
α-Linked spacer arms, suitable for coupling on a protein carrier, have been introduced directly on GlcNAc and on Gal-β(1-3)GalNAc in a 1,2-cis fashion through a new procedure involving a completely stereoselective Michael addition of the anomeric sodium alcoholate onto β-tosyloxy acrolein prepared in situ from the sodium salt of malonaldehyde and tosyl chloride.Keywords
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