Studies on Pyruvate Kinase (PK) Deficiency
- 1 December 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 74 (6) , 1165-1175
- https://doi.org/10.1093/oxfordjournals.jbchem.a130344
Abstract
1. Previous findings that three types of pyruvate kinase [EC 2.7.1.40] (PK) are present in human tissues were confirmed and these PK's were partially characterized. Their distribution in human tissues was almost identical to that in rat tissues. Results of electrophoretic, immunological, and kinetic studies on erythrocyte PK suggested that it might be a hybrid of L and M2 subunits. 2. On the basis of these fundamental results, the PK in erythrocytes and other tissues (i.e., liver, muscle, spleen, and adipose tissues) of human subjects with two typical types of PK deficiency was analyzed. Case M.I. (PK “ Beppu”) showed quantitative abnormality of erythrocyte PK and liver L-PK, while Mi (muscle) and M2 (spleen and adipose tissue) were normal. In cases Y.K. and F.K. (PK “Tokyo”), qualitative abnormality of erythrocyte PK and liver L-PK was found, while M1 (muscle) and M2 (spleen and adipose tissue) were normal as in case M.I.Keywords
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