Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
- 13 February 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5660) , 1014-1016
- https://doi.org/10.1126/science.1090839
Abstract
The structure of an RNA polymerase II–transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.Keywords
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