A New Phosphorylating Reagent. III. Preparation of Mixed Diesters of Phosphoric Acid by the Use of an Activatable Protecting Group
- 1 January 1971
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 44 (1) , 232-235
- https://doi.org/10.1246/bcsj.44.232
Abstract
A novel method for the preparation of mixed diesters of phosphoric acid has been investigated. It was found that mixed diesters of phosphoric acid were prepared by the reaction of alkyl 2-chloromethyl-4-nitrophenyl hydrogen phosphates with alcohols in dry pyridine. On the other hand, these diesters were also obtained from dialkyl 2-chloromethyl-4-nitrophenyl phosphates on hydrolysis under mild conditions. By using both of these methods, analytically pure samples of mixed diesters of phosphoric acid could be obtained in high yields.Keywords
This publication has 1 reference indexed in Scilit:
- New phosphorylating reagent. I. Preparation of alkyl dihydrogen phosphates by means of 2-chloromethyl-4-nitrophenyl phosphorodichloridateJournal of the American Chemical Society, 1969