252Cf Plasma Desorption Mass Spectrometry: Recent Advances and Applications

Publisher Website
Google Scholar
Abstract
252Cf plasma desorption mass spectrometry (PDMS) as utilized in the BIO-ION instruments is described. The sensitivity of the technique is investigated for varying amounts of bovine insulin. The results show accurate mass assignment for pmole amounts of sample. Several methods, currently used for sample preparation in PDMS, are described. Spectra of the antibiotic nisin (3,354.1 Dalton) using two different sample preparation techniques show significant variation. The fragmentation pattern of reduced acetylated maltoheptaose (2,119.9 Dalton) is also presented. The initial results obtained using a new PDMS instrument equipped with a variable flight path are shown. The increased resolution is illustrated using the extended flight path to measure the molecular ion region of the maltoheptaose.