Relaxations mediated by adrenergic and non-adrenergic nerves in human isolated taenia coli
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1) , 533-537
- https://doi.org/10.1111/j.2042-7158.1977.tb11390.x
Abstract
In human taenia coli electrical field stimulation after cholinergic blockade excited mainly non-adrenergic inhibitory nerves. Adrenergic relaxations during stimulation were demonstrated only with short electrical pulses at high frequencies or with ganglion stimulants. Reduction by tetrodotoxin of relaxations to indirectly acting sympathomimetics supports the histochemical finding that colonic adrenergic nerves are mainly preganglionic, and possibly synapse with non-adrenergic inhibitory nerves. When the latter undergo direct maximal stimulation, responses to adrenergic nerve excitation are masked.This publication has 28 references indexed in Scilit:
- The intrinsic innervation of the human alimentary tract and its relation to function.Gut, 1975
- Stimulating action of catecholamines on isolated preparations of the rat colon and human and rabbit taeniae coliBritish Journal of Pharmacology, 1971
- Inhibition of tone in the taenia of the Guinea pig caecumEuropean Journal of Pharmacology, 1969
- Further evidence for the presence of non-adrenergic inhibitory structures in the guinea-pig colonEuropean Journal of Pharmacology, 1968
- Adrenergic myenteric nerves in Hirschsprung's disease.BMJ, 1968
- Über die Verteilung von Catecholaminen im Darm des MenschenCell and tissue research, 1967
- Inhibition of the taenia of the guinea-pig caecum by acetylcholine, nicotine or 5-hydroxytryptamineJournal of Pharmacy and Pharmacology, 1966
- The effects of adrenalectomy and fasting on intestinal function in the ratThe Journal of Physiology, 1965
- A PRELIMINARY INVESTIGATION OF THE PHARMACOLOGY OF THE HUMAN ISOLATED TAENIA COLI PREPARATIONBritish Journal of Pharmacology and Chemotherapy, 1964
- The release of chemical transmitter from the sympathetic nerves of the intestine of the catThe Journal of Physiology, 1958