Differential Expression of Natural Killer Receptors on Vδ1 γδ T Cells in HIV-1-Infected Individuals
- 1 August 2003
- journal article
- Published by Wolters Kluwer Health in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 33 (4) , 420-425
- https://doi.org/10.1097/00126334-200308010-00002
Abstract
γδ T cells expressing the Vδ1 T-cell receptor are increased in HIV-1-infected individuals. Since T-cell activation is modulated by inhibitory and activating natural killer receptors (NKRs), we investigated the expression of NKRs on Vδ1 T cells in 22 HIV-1 infected patients by 2-color flow cytometry. We observed a strongly increased expression of several NKRs on ex vivo analyzed Vδ1 T cells from HIV+ patients. Furthermore, we show that the in vitro stimulation of CD94− Vδ1 T cells induced strong expression of inhibitory NKR CD94/CD159A (NKG2A). Our results suggest that the increased expression of NKRs might result from chronic activation of Vδ1 T cells in HIV-1-infected persons.Keywords
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