ERYTHROCYTE GLUTATHIONE METABOLISM IN COBALT-DEFICIENT GOATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 46  (2) , 165-172
Abstract
Co deficiency was produced in goats by feeding them rhodes grass hay. The deficient animals excreted increased amounts of methyl malonic acid in their urine, indicating a lack of vitamin B12. Erythrocyte reduced glutathione levels increased with the onset of anemia. There was a concomitant increase in the levels of erythrocyte glutathione reductase (GSSG: NADPH reductase) and glutathione peroxidase (GSH: H2O2 peroxidase) during deficiency. These results are compared with similar observations reported for vitamin B12 deficiency in humans.