CELLULAR ATTACHMENT TO IMPLANTED FOREIGN-BODIES IN RELATION TO TUMORIGENESIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (12) , 4367-4371
Abstract
Previous experiments demonstrating a reduction of tumorigenicity by roughening the surfaces of plastics implanted in rodents, or by increasing the pore size of cellulose filter implants, were repeated with observations on cellular attachment to these objects and filters strengthened and made impermeable by bonding to plastic. Round 13-mm discs of methylmethacrylate implanted s.c. in A/BiF per F50+ mice produced sarcomas in 12% of mice at 64 wk. Tumor incidence increased to 60% (P < 0.001) in mice receiving discs to which cellulose filters with pore sizes of 0.025-0.1 .mu.m were bonded. No tumors occurred with discs covered by 0.45-.mu.m filters, followed up to 83 wk. Vinyl coverslips 15 mm square also produced no sarcomas when covered by 0.45-.mu.m filters. Plain vinyl produced sarcomas in 40% of mice at 64 wk (P < 0.001). Sanding of vinyl surfaces reduced tumorigenicity (P < 0.05). Permeability, fragility and storage capacity of filters are apparently not related to tumorigenicity. Surface roughness probably is related. Cells, mostly macrophages, were densely and uniformly attached to nontumorigenic surfaces from 24 h to 2 yr after implantation but were distinctly fewer and not uniformly distributed on tumorigenic surfaces. Topology favoring attachment was inherent in 0.45-.mu.m filters and was produced in plastic by gouging irregular excavations 10-15 .mu.m deep.

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