Intravitreal Toxicity of Hydroxyacyclovir (BW-B759U), a New Antiviral Agent
- 1 June 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 103 (6) , 840-841
- https://doi.org/10.1001/archopht.1985.01050060100036
Abstract
• We investigated the toxicity of the antiviral compound hydroxyacyclovir (9-[hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or BW-B759U), following intravitreal injection in the rabbit. Intravitreal doses of 10, 20, 40, 80, 100, 200, and 400 μg produced no discernible ophthalmoscopic or histologic changes. Intravitreal doses of 40, 200, and 400 μg produced no changes in the electroretinography B-waves. The low level of retinal toxicity and excellent median inhibitory dose values of intravitreal BW-B759U against cytomegalovirus suggest its potential therapeutic utility in the treatment of cytomegalovirus retinitis.This publication has 5 references indexed in Scilit:
- Effects of the nucleoside analog 2'-nor-2'-deoxyguanosine on human cytomegalovirus replicationAntimicrobial Agents and Chemotherapy, 1984
- Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitroAntimicrobial Agents and Chemotherapy, 1983
- Cytomegalovirus Retinitis in Immunosuppressed HostsAnnals of Internal Medicine, 1980
- Stimulation of Cellular Thymidine Kinases by Human CytomegalovirusJournal of Virology, 1977