Evidence for Species Specificity in the Interaction between Thyrotropin and Thyroid-Stimulating Immunoglobulin and Their Receptor in Thyroid Tissue*

Publisher Website
Google Scholar
Abstract
The cAMP response in cultured human and dog thyroid cells was used to examine the relationship betweenhuman TSH, nonprimate thyroid-stimulating immunoglobulin (TSI) bioactivity in hunand nonhuman thyroid tissue. The bovine TSH (bTSH) to million TSH potency ratio was approximately 6-fold greater in dog than in human thyroid cells. Relative bioactivity of bTSH and TSI also differed these cell types. Thus, four TSI samples produced approximately 6- fold greater stimulation relative to bTSH in human thyroid than in dog thyroid cells. It is discussed why these data suggest that the TSH receptor as well as TSH and TSI display species specificity as defined by the classical concept of this term. (J Clin Endocrinol Metab54: 1059,1982)