CONNECTIVE TISSUE METABOLISM IN SWINE: II. INFLUENCE OF ENERGY LEVEL AND ASCORBATE SUPPLEMENTATION ON HYDROXYPROLINE EXCRETION

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Abstract
The influence of the level of energy and ascorbate supplementation on hydroxyproline excretion in swine was studied in a 3 × 3 factorial experiment using 36 weanling, male Yorkshire swine. There were three levels of energy, 140, 240 and 340 kcal per kg W0.75 of metabolizable energy (ME) per day and three levels of ascorbate, nil, 500 and 1000 mg per day. An apparent complex interaction between energy level and level of ascorbate supplementation on hydroxyproline excretion was found. When ascorbate intake levels were increased to 1000 mg per day, there was a significant increase in total hydroxyproline excretion per kg of body weight with increased energy intake. This was not observed at ascorbate levels of 0 and 500 mg per day. When the influence of ascorbate supplementation within energy groups was examined, it was found that hydroxyproline excretion decreased significantly when the animals received 240 kcal per kg W0.75 of ME per day, and increased when the level of energy intake was 340 kcal per kg W0.75 of ME per day. Since urinary hydroxyproline is derived mainly from bone, these data suggest that 1000-mg levels of ascorbate, when combined with a high level of energy, in this case 340 kcal per kg W0.75, may increase the catabolism of bone matrix; on the other hand, when energy is limited, supplementary ascorbate may increase polymerization of precursor collagen into stable forms.

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