AMOBARBITAL METABOLISM IN MAN - N-GLUCOSIDE FORMATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 21  (1) , 45-53
Abstract
N-Hydroxyamobarbital, the compound previously proposed as the 2nd major metabolite of amobarbital, was synthesized. The metabolite was shown not to be N-hydroxyamobarbital. NMR and MS [mass spectroscopy] analyses on the metabolite suggested it could be a derivative of N-.beta.-D-glucopyranoside. This proposed structure was confirmed by comparison with the spectral data of synthetic amobarbital-N-methyl-N-2,3,4,6-tetraacetyl-.beta.-D-glucopyranoside.

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