Enzyme Release from Polymorphonuclear Leukocyte Lysosomes: Regulation by Autonomic Drugs and Cyclic Nucleotides
- 15 June 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 180 (4091) , 1181-1183
- https://doi.org/10.1126/science.180.4091.1181
Abstract
Osmotic release of β-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3',5'-monophosphate, and accelerated by cholinergic agents and guanosine 3',5'-monophosphate. These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5'-monophosphate and guanosine 5'-monophosphate do not inodify lysosomal enzyme release.Keywords
This publication has 15 references indexed in Scilit:
- Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritisBiochemical Pharmacology, 1972
- Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liverBiochemical Pharmacology, 1971
- Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitroBiochemical Pharmacology, 1971
- Cyclic NucleotidesAnnual Review of Physiology, 1971
- Role of catecholamines in inflammationEuropean Journal of Pharmacology, 1970
- Studies of adjuvant-induced arthritis in the albino rat (CFN strain).Annals of the Rheumatic Diseases, 1970
- Prevention of Experimental Allergic Encephalomyelitis by Combination of Epinephrine and a Phenothiazine Derivative, PropiomazineExperimental Biology and Medicine, 1969
- β-Adrenergic receptors in human plateletsJournal of Atherosclerosis Research, 1969
- Histamine Release in vitro: Inhibition by Catecholamines and MethylxanthinesScience, 1968
- The Role of Lysosomes in Inflammation and DiseaseAnnual Review of Medicine, 1967