Effect of long-term training and acute physical exercise on red cell 2,3-diphosphoglycerate

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Abstract
A statistically significant 10% increase (pspVO2 max) was observed in 29 recruits, who were studied during 6 months of physical training in military service. The increase in 2,3-DPG was higher, the lower the initial 2,3-DPG and VO2 max levels. The mean initial 2,3-DPG level was higher in the subjects with a higher initial VO2 max. A strenuous but highly aerobic 21-km marching exercise elicited a mean 9% increase (pVO2 max than in those with a higher pre-test VO2 max. During another more competitive march 2,3-DPG remained almost unchanged and was associated with a tendency towards a negative correlation with the accompanying lactate response (r=−0.60, p<0.05). Red cell 2,3-DPG response to a standardized exercise is considered to be a suitable indicator for evaluating the effect of training on an individual.