Infidelity of DNA Synthesis in Vitro: Screening for Potential Metal Mutagens or Carcinogens
- 24 December 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 194 (4272) , 1434-1436
- https://doi.org/10.1126/science.1006310
Abstract
Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.This publication has 30 references indexed in Scilit:
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