Biopharmaceutical study of the hepato-biliary transport of drugs. VII. Improvement of the bioavailability of rifampicin by dosage form design.
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 26 (1) , 19-24
- https://doi.org/10.1248/cpb.26.19
Abstract
Improvement of the bioavailability of rifampicin (RFP) was attempted by dosage form design. As lipid vehicles, sesame oil, soybean oil, oleic acid and middle chain triglyceride (MCT) such as tricapriline, were employed. When sesame oil or MCT was used as a lipid vehicle, the percentage recovery of RFP into rat bile was significantly decreased and rat serum RFP level was increased. This improvement of the bioavailability of RFP was also occurred in a dog. The mechanism by which the bioavailability of RFP was improved by lipid vehicles was studied and it has been revealed that this improvement of the bioavailability of RFP is not due to its depressed hepatic uptake from the blood stream after absorption from the gastrointestinal tract but due to the depressed active biliary excretion from the hepatocytes into the bile.Keywords
This publication has 2 references indexed in Scilit:
- Biopharmaceutical study of the hepatobiliary transport of drugs. VI. Inhibition of active biliary excretion of organic cations by retrograde infusion.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- Biopharmaceutical study of the hepato-biliary transport of drugs. IV. Development of the method to investigate the process of the active secretion of drugs from the hepatocytes into the bile canaliculi and its application to the biliary excretion of organic anions in rat.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976