PROPRANOLOL EFFECT ON RENIN-ANGIOTENSIN SYSTEM KINETIC DURING EXPERIMENTAL HYPERTHYROIDISM

  • 1 January 1982
    • journal article
    • research article
    • Vol. 38  (1) , 35-40
Abstract
The basal levels of angiotensin I (AI), plasma renin activity (PRA), plasma renin substrate (PRS) and plasma renin concentration (PRC) were estimated in hyperthyroid rats before and after propranolol treatment. Serum levels of triiodothyronine (T3), thyroxine (T4), AI both basal and generated by incubation of plasma samples were measured by radioimmunoassay, while PRC and PRS were evaluated by kinetic methods. The hyperthyroidism provoked by T3 or T4 treatment induced a decrease in PRS and an increase in PRC whereas T3 alone produced an increase in the basal levels of AI and PRA. The propranolol in euthyroid animals not only decreased the basal levels of AI and PRA, but also prevented the PRC increase in hyperthyroid rats, while restoring at the same time the basal levels of AI and PRA.