Intracellular Protein Resembling Russell Bodies in Malignant Lymphomas Associated with Acquired Hemolytic Anemia

Abstract
Large amounts of intracellular protein, resembling Russell bodies chemically and reacting positively with periodic acid Shiff reagent were found in the neoplastic cells of 3 patients with malignant lymphoma and hemolytic anemia and positive Coombs'' tests. A similar protein was found in 7 of 65 unselected cases of malignant lymphoma. Some of these showed evidence of hemolytic anemia.

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